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Image Search Results
Journal: Frontiers in Endocrinology
Article Title: Coordinated regulation of gene expression and microRNA changes in adipose tissue and circulating extracellular vesicles in response to pioglitazone treatment in humans with type 2 diabetes
doi: 10.3389/fendo.2022.955593
Figure Lengend Snippet: Expression and associations among AT genes found to be overtargeted by the DE EV-miRNAs. (A-E) Profiles of differentially expressed overtargeted AT genes. (F, G) Profiles of pro-apoptotic BAX and CASP3 genes in AT. (G-J) Significant correlations between the change in DE overtargeted AT genes and the change in circulating DE EV-miRNA and AT-miRNAs. (K) Correlation network of significant ( P <0.05, FDR<0.1) associations among AT genes involved in miRNA biogenesis/exosomal sorting, experimentally validated AT genes overtargeted by the DE EV-miRNAs (orange ovals), and clinical measures relevant to lipid metabolism (green octagons), body composition (grey octagons), glycemic control (cyan octagons), and β cell function (purple octagons). (L-Z) Correlation plots between the change in DE AT genes and the change in relevant clinical measures. Waist circ or wstcirc, waist circumference; FPG, fasting plasma glucose; FPI, fasting plasma insulin; AUC.insulin, insulin area under the curve; FFM, free fat mass; FFA, free fatty acids; K_FFA or ffa.K, rate of free fatty acid disappearance; LDL, low density lipoprotein; HDL, high density lipoprotein; Adipo.IR, insulin resistance in adipose tissue.
Article Snippet: Free fatty acids (FFA) were measured using the HR
Techniques: Expressing, Control, Cell Function Assay